Published prospective
clinical trials
Research in Cairo Cure

Journal: ESMO Open
Year: 2025
Cairo Cure member: Hamdy A. Azim, Loay Kassem, Shaimaa Lasheen & Hagar Elghazawy
Brief Description: A prospective study evaluating BRCA1/2 pathogenic variants (PVs) in Northern African countries using next-generation sequencing (NGS)-based testing in patients with epithelial ovarian (EOC) and triple-negative breast cancer (TNBC)
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Journal: Jounal of Clinical Oncology
Year: 2024
Cairo Cure member: Hamdy A.Azim
Brief Description: Randomized clinical trial showing superiority of CDK 4/6 inhibitors and hormonal therapy to chemotherapy in premenopausal women with advanced breast cancer
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Journal: The Breast
Year: 2022
Cairo Cure member: Hamdy A.Azim
Brief Description: This is an international trial involving thousands of women that evaluated novel formulation of the targeted treatment trastuzumab in managing breast cancer. This study led to the FDA approval of the subcutaneous form of trastuzumab which is now being used in clinical practice.
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Journal: Breast Cancer Research & Treatment
Year: 2021
Cairo Cure member: Hamdy A. Azim
Brief Description: This is an international trial involving thousands of women that evaluated the targeted therapy ribociclib in patients with advanced breast cancer.
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Journal: Journal of Global Oncology
Year: 2019
Cairo Cure member: Hamdy A.Azim
Brief Description: This is a regional clinical trial that Cairo Cure participated in, that evaluated sorafinib in managing patients with advanced kidney cancer. This study allowed Cairo Cure to offer their patients early access to sorafinib, many years before its availability on the market.
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Journal: Journal Hepatocellular Carcinoma
Year: 2018
Cairo Cure member: Hamdy A. Azim
Brief Description: This is a clinical trial that was done in Egypt involving other Egyptian hospitals that evaluated the combination with sorafinib and UFT, a form of chemotherapy, in managing advanced liver cancer.
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Journal: The Oncologist
Year: 2018
Cairo Cure member: Hamdy A. Azim
Brief Description: This is an international trial involving thousands of women that evaluated novel formulation of the targeted treatment trastuzumab in managing breast cancer. This study led to the FDA approval of the subcutaneous form of trastuzumab
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Journal: Molecular & Clinical Oncology
Year: 2015
Cairo Cure member: Hamdy A. Azim
Brief Description: This is a regional clinical trial that Cairo Cure participated in, that evaluated sorafinib in managing patients with advanced kidney cancer. This study allowed Cairo Cure to offer their patients early access to sorafinib, many years before its availability on the market.
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Journal: Lancet Oncology
Year: 2013
Cairo Cure member: Hamdy A. Azim
Brief Description: This is an international trial involving thousands of women that evaluated novel form of chemotherapy in managing breast cancer. This study led to the FDA approval of docetaxel which is since then is a widely used drug in managing early breast cancer. Cairo Cure took part in this study, allowing Cairo Cure patients to have access to this novel drug, many years before its availability in the Egyptian market.
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Journal: BMC Cancer
Year: 2012
Cairo Cure member: Hamdy A. Azim
Brief Description: Cairo Cure took part in this regional clinical trial that involved hundreds of patients and evaluated pemetrexed chemotherapy in managing advanced lung cancer.
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Journal: The Breast
Year: 2012
Cairo Cure member: Hamdy A. Azim
Brief Description: Cairo Cure took part in an international clinical trial that involved hundreds of women and evaluated the combination of the targeted therapy trastuzumab and the hormonal therapy letrozole in managing advanced breast cancer.
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Journal: New England Journal of Medicine
Year: 2011
Brief Description: This is an international trial involving thousands of women that evaluated the targeted therapy trastuzumab in patients with early breast cancer. This study led to the FDA approval of trastuzumab which since then is a widely used drug in managing early breast cancer. Cairo Cure took part in this study, allowing Cairo Cure patients to have access to this novel drug, many years before its availability in the Egyptian market. This study was published in the New England Journal of Medicine, which is most reputed journal in all domains of medicine, being a study with huge impact on clinical practice.
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Journal: Lung Cancer
Year: 2011
Brief Description: This is an international clinical trial that involved thousands of patients and evaluated the targeted therapy erlotinib in managing patients with advanced breast cancer. Cairo Cure took part in this study, allowing Cairo Cure patients to have access to this novel drug, many years before its availability on the Egyptian market.
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Journal: Journal of the National Cancer Institute
Year: 2025
Cairo Cure member: Hatem A. Azim
Brief Description: Evaluating the impact of breastfeeding on breast cancer outcome in women with history of breast cancer and harbor a BRCA mutation
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Journal: Lancet Oncology
Year: 2025
Cairo Cure member: Hatem A. Azim
Brief Description: A large global study evaluating the association between risk reducing surgery and outcome in breast cancer patients harboring BRCA mutation
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Journal: European Journal of Cancer
Year: 2025
Cairo Cure member: Hatem A. Azim
Brief Description: A large study evaluating the use of assisted reproduction to become pregnancy in breast cancer patients harboring a BRCA mutation
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Journal: Oncologist
Year: 2025
Cairo Cure member: Hagar Elghazawy & Hamdy A. Azim
Brief Description: Evaluating the correlation between TROP2 expression with pathological features and survival in women with breast cancer
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Journal: Therapy Advanced Medical Oncology
Year: 2023
Cairo Cure member: Hamdy A. Azim
Brief Description: A large Egyptian study evaluating treatment patterns and survival outcomes of patients with advanced stage III non-small cell lung cancer
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Journal: Oncology Therapy
Year: 2023
Cairo Cure member: Hamdy A. Azim, Hatem A. Azim, Loay Kassem, & Nermine S. Kamal
Brief Description: Cairo Cure published the largest Egyptian series the characterization of BRCA mutation in Egyptian breast cancer patients
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Journal: Journal of Global Oncology
Year: 2023
Cairo Cure member: Hamdy A. Azim, Hagar Elghazawy, Loay Kassem
Brief Description: Cairo Cure published the largest series to date on characteristics of breast cancer diagnosed in Egyptian women
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Journal: Translational Oncology
Year: 2016
Cairo Cure member: Hamdy A. Azim & Loay Kassem
Brief Description: This is an international collaboration with leading cancer centers in France to evaluate novel resistance mechanisms for patients with certain forms of breast cancer
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Journal: Women’s Health (Lond)
Year: 2014
Cairo Cure member: Hamdy A. Azim & Hatem A. Azim
Brief Description: This research is conducted in Cairo Cure and evaluated the largest series published in the Middle east on lobular cancer, which is an uncommon form of breast cancer
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Journal: Ecancermedicalscience
Year: 2013
Cairo Cure member: Hamdy A. Azim, Nermine S. Kamal, Rehab Tolba & Alaa Hamdy
Brief Description: A study to evaluate low dose rasburicase in controlling tumor lysis syndrome in patients with hematological cancers.
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Journal: The Breast
Year: 2011
Cairo Cure member: Hamdy A. Azim
Brief Description: Cairo Cure took part in a survey that evolved leading cancer centers in the Arab region evaluating different practices of breast cancer across the MENA region
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Journal: Biomarkers
Year: 2022
Cairo Cure member: Hamdy A. Azim & Loay Kassem
Brief Description: This is a large meta-analysis on the association between PDL1 expression and response to neoadjuvant chemotherapy in patients with triple negative breast cancer
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Journal: Current Problems in Cancer
Year: 2020
Cairo Cure member: Hamdy A. Azim, Loay Kassem & Hatem A. Azim
Brief Description: This is a meta-analysis on the value of ovarian function suppression in the adjuvant therapy of young breast cancer patients.
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Journal: European Journal of Cancer
Year: 2011
Cairo Cure member: Hatem A. Azim & Hamdy A. Azim
Brief Description: This is a meta-analysis evaluating safety of pregnancy in women with history of breast cancer
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Journal: Lung Cancer
Year: 2011
Cairo Cure member: Hatem A. Azim & Hamdy A. Azim
Brief Description: This is a meta-analysis evaluating triplet chemotherapies in patients with advanced/metastatic non-small cell lung cancer
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Journal: Cancer Treatment Reviews
Year: 2025
Cairo Cure member: Hatem A. Azim
Brief Description: This is an international expert analysis on the use of estrogen containing vaginal creams to treat vaginal dryness in young women with breast cancer
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Journal: Annals of Oncology
Year: 2023
Cairo Cure member: Hatem A. Azim
Brief Description: This is a consensus statement by the European Society of Medical Oncology (ESMO) on managing breast cancer during pregnancy issued in 2023. Dr. Hatem A. Azim featured among group of international experts to define key aspects on managing this disease.
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Journal: Cancers (Basel)
Year: 2021
Cairo Cure member: Hamdy A. Azim
Brief Description: This is a consensus statement issued by the BGICC on the management of triple negative breast cancer in 2021. Dr. Hamdy A. Azim featured among group of international experts to define key aspects on managing this disease.
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Journal: Annals of Oncology
Year: 2020
Cairo Cure member: Hatem A. Azim
Brief Description: this is an international guideline issued by the European School of Oncology (ESO) and the European Society of Medical Oncology (ESMO) on managing breast cancer in young women in 2020. Dr. Hatem A. Azim featured among group of international experts to define key aspects on managing this disease.
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Journal: BMC Medicine
Year: 2016
Cairo Cure member: Hatem A. Azim
Brief Description: this is a consensus statement organized by the University of Genoa in Italy on fertility aspects in cancer patients in 2016. Dr. Hatem A. Azim featured among group of international experts to define key aspects on fertility counselling in patients diagnosed with cancer.
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Journal: The Breast
Year: 2014
Cairo Cure member: Hamdy A. Azim
Brief Description: this is a consensus statement on preserving bone health in breast cancer patients. Dr. Hatem A. Azim features among group of international experts to define key aspects on this matter.
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Journal: The Breast
Year: 2014
Cairo Cure member: Hatem A. Azim
Brief Description: This is the first ever guidelines issued by an international organization; the European School of Oncology (ESO) on managing breast cancer in young women in 2014. Dr. Hatem A. Azim featured among group of international experts
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Journal: Annals of Oncology
Year: 2013
Cairo Cure member: Hatem A. Azim
Brief Description: Dr. Hatem A. Azim features among group of international experts issuing recommendations and guidelines on managing pregnant cancer patients
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Journal: Annals of Oncology
Year: 2013
Cairo Cure member: Hatem A. Azim
Brief Description: This is an international guidelines evaluating the role of genomic tests in deciding the need for chemotherapy in women with early breast cancer in 2013. Dr. Hatem A. Azim is the leading author and featured among group of international experts
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Journal: Journal of NCCN
Year: 2010
Cairo Cure member: Hamdy A. Azim
Brief Description: This is a Middle East version of the NCCN guidelines for managing malignant lymphomas. Dr. Hamdy Azim, the leader of this initiative discuss adapting international guidelines to the needs of the Middle East region.
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